Project Title: Using Published Summary Data to Assess Causal Relationships between Sleep Habits and the Risk of Lung Cancer
BASIS Advisor: Dr. Ryan Grove
Internship Location: GW Columbian College of Arts & Sciences
Onsite Mentor: Dr. Hua Liang
In 2017, the International Agency for Research on Cancer declared “shift work leading to a disruption of circadian rhythm” as likely carcinogenic to humans. Disrupted sleep and exposure to light at night are among several hypothetical mechanisms that might link circadian rhythm disruption to cancer. It is not clear whether certain sleep habits can directly affect the risk of lung cancer (LC). Using publicly available summarized results from large scale genome-wide association studies (GWAS) on four sleep traits, including two chronotype-related traits (one with 2 levels, the other with 5 levels), sleep duration (hours of sleep), and insomnia (defined as never/rarely vs. frequent insomnia symptoms), and summarized results from a lung cancer GWAS, we will conduct Mendelian Randomization (MR) analyses in R to evaluate the potential causal effect from each considered sleep trait on the development of LC and summarize results in a research report. Each MR analysis uses selected genetic markers (i.e., single nucleotide polymorphisms (SNPs)) as proxies for the sleep trait to assess its direct effect on LC.
Hello everyone and welcome back to my blog! This week, I searched for the public summary data necessary to carry out the analysis part of my project. There are multiple sets of data to extract, so it is important to understand what is needed and why. As explained in my introduction blog, the idea behind […]
Welcome back to my blog! It’s been many months since I last touched statistics, so this week was all about review and preparation. Monday and Tuesday were spent skimming through the AP Statistics curriculum using The Practice of Statistics, with emphasis on conducting significance tests and creating confidence intervals. For the remainder of the week, […]
Hello everyone, My project will use Mendelian Randomization and R to assess whether a relationship exists between sleep habits (chronotype, duration, etc.) and lung cancer. In 2019, California signed a state law that would delay school start times past 8:30 A.M with the intention of improving teenagers’ health. Though the impact of the law is […]