Project Title: Improving the Treatment of Alzheimer's Disease through Ultrasonic Disruption of the Blood-Brain Barrier
BASIS Advisor: Dr. Nancy Fisher
Internship Location: George Mason University Krasnow Institute
Onsite Mentor: Professor Robert J. Cressman
The purpose of this study is to determine whether ultrasonic treatment of Alzheimer’s disease can be improved. In particular, the research will examine the impact of endothelial cell dehydration on blood-brain barrier permeability. This dehydration will be fueled by ultrasound-induced polymer degradation around endothelial cell membranes. Since animal subjects will not be used, lab materials must replicate the body’s biological components. An artificial membrane will simulate the blood-brain barrier. Potential ultrasound-responsive polymers for experimentation include polyethylene oxide (PEO), polylactic acid (PLA), and citrus pectin. Changes in light intensity will be measured across the artificial blood-brain barrier to determine whether polymer degradation created osmotic pressure differences.
The past two weeks of my internship have been quite exciting. I began by doing a bit of reading on Transwell plates, liposomes, and epilepsy. In short, the documents I looked over were meant to update me on recent progress in the Cressman lab. I also found out that my Professor is working with a […]
Hi everyone, welcome to my first blog post! My name is Kamil, and I’m a BASIS senior interested in neuroscience and biomedical engineering. Throughout my senior project, I will be working with Professor John R. Cressman at George Mason University’s Krasnow Institute. I intend to continue the research I conducted last summer, which focused on […]